Tuning Monoclonal Antibody Galactosylation using Raman Spectroscopy
Tuning Monoclonal Antibody Galactosylation using Raman Spectroscopy-Controlled Lactic Acid Feeding
A key aspect of large-scale production of biotherapeutics is a well-designed and consistently-executed upstream cell culture process. Process Analytical Technology (PAT) tools provide enhanced monitoring and control capabilities to support consistent process execution, and also have potential to aid in maintenance of product quality at desired levels.
One such tool, Raman spectroscopy, has matured as a useful technique to achieve real-time monitoring and control of key cell culture process attributes. We developed a Raman spectroscopy-based nutrient control strategy to enable dual control of lactate and glucose levels for a fed-batch CHO cell culture process for monoclonal antibody (mAb) production.
To achieve this, PLS-based chemometric models for real-time prediction of glucose and lactate concentrations were developed and deployed in feedback control loops. In particular, feeding of lactic acid post-metabolic shift was investigated based on previous work that has shown the impact of lactate levels on ammonium as well as mAb product quality.
Three feeding strategies were assessed for impact on cell metabolism, productivity, and product quality: bolus-fed glucose, glucose control at 4 g/L, or simultaneous glucose control at 4 g/L and lactate control at 2 g/L. The third feeding strategy resulted in a significant reduction in ammonium levels (68%) while increasing mAb galactosylation levels by approximately 50%.
This work demonstrated that when deployed in a cell culture process, Raman spectroscopy is an effective technique for simultaneous control of multiple nutrient feeds, and that lactic acid feeding can have a positive impact on both cell metabolism and mAb product quality. This article is protected by copyright. All rights reserved.
PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7) |
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| TA502611 | Origene Technologies GmbH | 100 µl | Ask for price |
PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7) |
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| TA502611S | Origene Technologies GmbH | 30 µl | Ask for price |
PON1 mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) |
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| TA502612 | Origene Technologies GmbH | 100 µl | Ask for price |
PON1 mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) |
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| TA502612S | Origene Technologies GmbH | 30 µl | Ask for price |
Monoclonal PON1 Antibody, Clone: 4G8D3 |
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| AMR09437G | Leading Biology | 0.1ml | EUR 633.6 |
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Description: A Monoclonal antibody against Human PON1. The antibodies are raised in Mouse and are from clone 4G8D3. This antibody is applicable in WB and IHC, FC, ICC, E |
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Rabbit Anti Human PON1 Monoclonal Clone ACAG-16 |
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| IRBAHUPON1ACAG16C100UL | Innovative research | each | EUR 496 |
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Description: Rabbit Anti Human PON1 Monoclonal Clone ACAG-16 |
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Monoclonal PON1 Antibody, Clone: 4G8A12 |
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| AMM02955G | Leading Biology | 0.1ml | EUR 633.6 |
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Description: A Monoclonal antibody against Human PON1. The antibodies are raised in Mouse and are from clone 4G8A12. This antibody is applicable in WB and IHC, FC, E |
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Monoclonal Antibody to Paraoxonase 1 (PON1) |
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| MAA243Ra21 | Cloud-Clone | 100ul | EUR 253 |
PON1 Mouse Monoclonal Antibody |
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| E10-30571 | EnoGene | 100 μl | EUR 275 |
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Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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PON1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI1F7 |
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| TA600112 | Origene Technologies GmbH | 100 µg | Ask for price |
PON1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI2A6 |
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| TA600113 | Origene Technologies GmbH | 100 µg | Ask for price |
PON1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI2D4 |
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| TA600114 | Origene Technologies GmbH | 100 µg | Ask for price |
Anti-PON1 Mouse Monoclonal Antibody [Clone ID: OTI1F7] |
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| M00516-4 | BosterBio | 100ul | EUR 523 |
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Description: Boster Bio PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7). Catalog# M00516-4. Tested in ELISA, FC, IHC, WB. This antibody reacts with Human. |
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Anti-PON1 Mouse Monoclonal Antibody [Clone ID: OTI2D4] |
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| M00516-5 | BosterBio | 100ul | EUR 523 |
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Description: Boster Bio PON1 mouse monoclonal antibody, clone OTI2D4 (formerly 2D4). Catalog# M00516-5. Tested in ELISA, FC, IF, IHC, WB. This antibody reacts with Human. |
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Mouse Monoclonal Antibody to PON1 |
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| E10-30571A | EnoGene | 100ul | EUR 225 |
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Description: Available in various conjugation types. |
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Mouse Monoclonal Antibody to PON1 |
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| E10-30572 | EnoGene | 100ul | EUR 225 |
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Description: Available in various conjugation types. |
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Mouse Monoclonal Antibody to PON1 |
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| sAP-0865 | Angio Proteomie | 50ug | EUR 270 |
Mouse Monoclonal Antibody to PON1 |
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| sAP-0866 | Angio Proteomie | 50ug | EUR 270 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527855-01mL | MyBiosource | 0.1mL | EUR 305 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527855-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527855-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527855-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527855-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527856-01mL | MyBiosource | 0.1mL | EUR 305 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527856-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527856-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527856-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
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| MBS8527856-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
Mouse Monoclonal PON1 Antibody (4G8D3) |
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| TA336952 | Origene Technologies GmbH | 100 µl | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI2D4 (formerly 2D4) |
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| CF502528 | Origene Technologies GmbH | 100 µg | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI2A6 (formerly 2A6) |
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| CF502610 | Origene Technologies GmbH | 100 µg | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7) |
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| CF502611 | Origene Technologies GmbH | 100 µg | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) |
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| CF502612 | Origene Technologies GmbH | 100 µg | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1A5 |
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| TA807382 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1A5 |
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| TA807382S | Origene Technologies GmbH | 30 µl | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1B12 |
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| TA807383 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1B12 |
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| TA807383S | Origene Technologies GmbH | 30 µl | Ask for price |
Mouse Anti-HCMV gH Monoclonal Antibody, clone MAb 5 |
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| CABT-NS1153 | Creative Diagnostics | 200 μg | EUR 830 |
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Description: Mouse |
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PON1 biotinylated detection antibody, ELISA and Luminex validated mouse monoclonal antibody, clone OTI2A6 |
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| TA700112 | Origene Technologies GmbH | 50 µg | Ask for price |
PON1 biotinylated detection antibody, ELISA and Luminex validated mouse monoclonal antibody, clone OTI2D4 |
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| TA700114 | Origene Technologies GmbH | 50 µg | Ask for price |
Mouse Anti-Ara h1 IgE Monoclonal Antibody (mAb), Clone 2G11G7 |
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| 7153 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Allergy |
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Mouse Anti-Ara h1 IgM Monoclonal Antibody (mAb), Clone 3A1E11 |
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| 7154 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Allergy |
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Mouse Monoclonal Anti-Mouse CD160 mAb, PE, (clone CNX46-3), (mouse IgG2bk) |
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| MCD160-PE | Alpha Diagnostics | 50 tests | EUR 416.4 |
CD20 (MS4A1) mouse monoclonal antibody, clone mAb 75 |
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| DDX0110P-100 | Origene Technologies GmbH | 100 µg | Ask for price |
KIR2DL4 mouse monoclonal antibody, clone mAb#33, PE |
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| AM26033RP-N | Origene Technologies GmbH | 100 Tests | Ask for price |
Mouse Monoclonal Anti-Mouse CD160 mAb, FITC, (clone CNX46-3), (mouse IgG2bk) |
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| MCD160-F | Alpha Diagnostics | 50 Tests | EUR 489.6 |
KIR2DL4 mouse monoclonal antibody, clone mAb#33, APC |
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| AM26033AC-N | Origene Technologies GmbH | 100 Tests | Ask for price |
Mouse Monoclonal Anti-Mouse CD160 mAb, Biotin, (clone CNX46-3), (mouse IgG2bk) |
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| MCD160-B | Alpha Diagnostics | 100 tests | EUR 562.8 |
PON3 mouse monoclonal antibody, clone OTI4H9 (formerly 4H9) |
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| TA807380 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI4H9 (formerly 4H9) |
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| TA807380S | Origene Technologies GmbH | 30 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5C3 (formerly 5C3) |
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| TA807381 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5C3 (formerly 5C3) |
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| TA807381S | Origene Technologies GmbH | 30 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5B5 (formerly 5B5) |
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| TA807428 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5B5 (formerly 5B5) |
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| TA807428S | Origene Technologies GmbH | 30 µl | Ask for price |
Mouse Monoclonal Anti-Mouse CD160 mAb, Purified, (clone CNX46-3), (mouse IgG2bk) |
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| MCD160-M | Alpha Diagnostics | 100 ug | EUR 578.4 |
PON3 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12) |
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| TA807353 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12) |
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| TA807353S | Origene Technologies GmbH | 30 µl | Ask for price |
Mouse Anti Mouse BDNF Monoclonal Clone |
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| IMSAMLBDNFC120UL | Innovative research | each | EUR 341 |
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Description: Mouse Anti Mouse BDNF Monoclonal Clone |
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Mouse Anti Mouse BDNF Monoclonal Clone |
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| MBS8421710-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti-Mouse Myeloperoxidase (MPO) IgM Monoclonal Antibody (mAb), Clone 8B3A6 |
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| 7160 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Inflammation |
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Mouse Anti-Mouse Myeloperoxidase (MPO) IgG3 Monoclonal Antibody (mAb), Clone 3B6A10 |
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| 7159 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Inflammation |
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KIR2DL4 mouse monoclonal antibody, clone mAb#33, Aff - Purified |
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| AM26033PU-N | Origene Technologies GmbH | 100 µg | Ask for price |
Ferritin mouse monoclonal antibody, clone mAb 44, Aff - Purified |
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| AM26062PU-N | Origene Technologies GmbH | 200 µg | Ask for price |
Mouse Anti Mouse TH Monoclonal Clone 5B7D10 |
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| IMSAMLTH5B7D10C120UL | Innovative research | each | EUR 282 |
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Description: Mouse Anti Mouse TH Monoclonal Clone 5B7D10 |
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Mouse Anti Mouse TH Monoclonal Clone 5B7D10 |
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| MBS8421747-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti Mouse GFAP Monoclonal Clone 3H1 |
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| IMSAMLGFAP3H1C120UL | Innovative research | each | EUR 260 |
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Description: Mouse Anti Mouse GFAP Monoclonal Clone 3H1 |
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Mouse Anti Mouse GFAP Monoclonal Clone 3H1 |
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| MBS8421725-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Rabbit Anti-Human PON1 Monoclonal Antibody |
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| CABT-36017RH | Creative Diagnostics | 100ug | EUR 1008 |
Mouse Anti Mouse tPA Monoclonal Clone H27B6 |
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| IMSAMSTPAH27B6C1MG | Innovative research | each | EUR 595 |
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Description: Mouse Anti Mouse tPA Monoclonal Clone H27B6 |
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Monoclonal Functional BAFF-R (mouse) Antibody, mAb , Clone: 9B9 |
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| APR16043G | Leading Biology | 0.1mg | EUR 633.6 |
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Description: A Monoclonal antibody against Human Functional BAFF-R (mouse), mAb . The antibodies are raised in Purified From Concentrated Hybridoma Tissue Culture Supernatant. and are from clone 9B9. This antibody is applicable in FC |
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Mouse monoclonal Anti-MOZ Clone 127A |
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| TA353278L | Origene Technologies GmbH | 500 µg | Ask for price |
ELISA andLuminex validated biotinylated detection antibody PON1 ELISA and Luminex validated mouse monoclonal antibody, clone OTI1F7 |
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| TA700113 | Origene Technologies GmbH | 50 µg | Ask for price |
Mouse Anti Mouse AIF1 Monoclonal Clone 5G4E7 |
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| IMSAMLAIF15G4E7C120UL | Innovative research | each | EUR 282 |
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Description: Mouse Anti Mouse AIF1 Monoclonal Clone 5G4E7 |
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Mouse Anti Mouse AIF1 Monoclonal Clone 5G4E7 |
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| MBS8421709-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse monoclonal Anti-BCL10 Clone 151 |
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| TA352997L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CDX1 Clone 123a |
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| TA353093L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse Anti-D. pteronyssinus Der p2 IgM Monoclonal Antibody (mAb), Clone 2D2B12 |
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| 7157 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Allergy |
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Mouse Anti-D. pteronyssinus Der p1 IgG3 Monoclonal Antibody (mAb), Clone 3H4E1 |
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| 7158 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Allergy |
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Mouse Anti Mouse GFAP Monoclonal Clone 2B12F1 |
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| IMSAMLGFAP2B12F1C120UL | Innovative research | each | EUR 282 |
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Description: Mouse Anti Mouse GFAP Monoclonal Clone 2B12F1 |
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Mouse Anti Mouse PPARG Monoclonal Clone 6D7B9 |
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| IMSAMLPPARG6D7B9C120UL | Innovative research | each | EUR 248 |
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Description: Mouse Anti Mouse PPARG Monoclonal Clone 6D7B9 |
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Mouse Anti Mouse GFAP Monoclonal Clone 2B12F1 |
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| MBS8421724-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti Mouse PPARG Monoclonal Clone 6D7B9 |
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| MBS8421743-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti-D. pteronyssinus Der p2 IgG2a Monoclonal Antibody (mAb), Clone 3H8D12 |
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| 7155 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Allergy |
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Mouse Anti-D. pteronyssinus Der p2 IgG2b Monoclonal Antibody (mAb), Clone 4C10H3 |
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| 7156 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
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Description: Allergy |
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Mouse monoclonal Anti-Mos Clone S3.1 |
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| TA353341L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse Anti Human TUBB3 Monoclonal Clone |
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| IMSAMLTUBB3C120UL | Innovative research | each | EUR 341 |
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Description: Mouse Anti Human TUBB3 Monoclonal Clone |
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Mouse Anti Human TUBB3 Monoclonal Clone |
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| MBS8421752-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse monoclonal Anti-EMA Clone E29 |
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| TA352816L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CR1 Clone To5 |
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| TA353107L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-p63 Clone BU5 |
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| TA353532L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-XPA Clone 5A2 |
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| TA353547L | Origene Technologies GmbH | 500 µg | Ask for price |
Lipoprotein lipase (LPL) mouse monoclonal antibody, clone Mab-7, Purified |
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| BM5512 | Origene Technologies GmbH | 50 µg | Ask for price |
Mouse monoclonal Anti-FCGR1 Clone 10.1 |
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| TA352787L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-p13 Clone AA10.2 |
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| TA352924L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-ANO5 Clone 5F7 |
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| TA352973L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD68 Clone KP1 |
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| TA353054L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Cdk1 Clone 3E1.1 |
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| TA353088L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Cdk2 Clone AN4.3 |
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| TA353089L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD29 Clone 8E3 |
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| TA353270L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP1 Clone 3B6 |
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| TA353335L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP2 Clone 4D3 |
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| TA353336L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP3 Clone 1B4 |
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| TA353337L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP9 Clone 2C3 |
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| TA353338L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MUC1 Clone SM3 |
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| TA353346L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Plx Clone AZ34 |
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| TA353386L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Plx Clone AZ44 |
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| TA353387L | Origene Technologies GmbH | 500 µg | Ask for price |
PON1 Rabbit Monoclonal Antibody |
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| E10G21865 | EnoGene | 100 μl | EUR 275 |
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Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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Mouse monoclonal Anti-APC11 Clone AX2.1 |
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| TA352969L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-APC4 Clone CIV1.1 |
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| TA352971L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD19 Clone BU12 |
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| TA353028L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD1c Clone M241 |
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| TA353030L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD22 Clone To15 |
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| TA353036L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD44 Clone P2A1 |
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| TA353042L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD44 Clone BU52 |
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| TA353043L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD70 Clone BU69 |
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| TA353057L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD72 Clone BU40 |
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| TA353059L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD86 Clone BU63 |
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| TA353067L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Leu2 Clone X107 |
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| TA353072L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Leu2 Clone BU88 |
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| TA353073L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Cdk2 Clone AN21.2 |
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| TA353090L | Origene Technologies GmbH | 500 µg | Ask for price |
Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action
- Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 within specific tumor microenvironments generates an immunosuppressive niche that effectively renders the tumor ‘invisible’ to the host’s immune system.
- Increased ARG2 expression leads to a concomitant depletion of local L-arginine levels, which in turn leads to suppression of anti-tumor T-cell-mediated immune responses. Here we describe the isolation and characterization of a high affinity antibody (C0021158) that inhibits ARG2 enzymatic function completely, effectively restoring T-cell proliferation in vitro. Enzyme kinetic studies confirmed that C0021158 exhibits a noncompetitive mechanism of action, inhibiting ARG2 independently of L-arginine concentrations.
- To elucidate C0021158’s inhibitory mechanism at a structural level, the co-crystal structure of the Fab in complex with trimeric ARG2 was solved. C0021158’s epitope was consequently mapped to an area some distance from the enzyme’s substrate binding cleft, indicating an allosteric mechanism was being employed. Following C0021158 binding, distinct regions of ARG2 undergo major conformational changes.
- Notably, the backbone structure of a surface-exposed loop is completely rearranged, leading to the formation of a new short helix structure at the Fab-ARG2 interface. Moreover, this large-scale structural remodeling at ARG2’s epitope translates into more subtle changes within the enzyme’s active site.
- An arginine residue at position 39 is reoriented inwards, sterically impeding the binding of L-arginine. Arg39 is also predicted to alter the pKA of a key catalytic histidine residue at position 160, further attenuating ARG2’s enzymatic function.
- In silicomolecular docking simulations predict that L-arginine is unable to bind effectively when antibody is bound, a prediction supported by isothermal calorimetry experiments using an L-arginine mimetic.
Specifically, targeting ARG2 in the tumor microenvironment through the application of C0021158, potentially in combination with standard chemotherapy regimens or alternate immunotherapies, represents a potential new strategy to target immune cold tumors.
Development of a physiologically-based pharmacokinetic model for ocular disposition of monoclonal antibodies in rabbits
- Development of protein therapeutics for ocular disorders, particularly age-related macular degeneration (AMD), is a highly competitive and expanding therapeutic area.
- However, the application of a predictive and translatable ocular PK model to better understand ocular disposition of protein therapeutics, such as a physiologically-based pharmacokinetic (PBPK) model, is missing from the literature.
- Here, we present an expansion of an antibody platform PBPK model towards rabbit and incorporate a novel anatomical and physiologically relevant ocular component.
- Parameters describing all tissues, flows, and binding events were obtained from existing literature and fixed a priori. First, translation of the platform PBPK model to rabbit was confirmed by evaluating the model’s ability to predict plasma PK of a systemically administered exogenous antibody.
- Then, the PBPK model with the new ocular component was validated by estimation of serum and ocular (i.e. aqueous humor, retina, and vitreous humor) PK of two intravitreally administered monoclonal antibodies.
- We show that the proposed PBPK model is capable of accurately (i.e. within twofold) predicting ocular exposure of antibody-based drugs. The proposed PBPK model can be used for preclinical-to-clinical translation of antibodies developed for ocular disorders, and assessment of ocular toxicity for systemically administered antibody-based therapeutics.
Development of High Resolution DNA Melting Analysis for Simultaneous Detection of Potato Mop-Top Virus and Its Vector, Spongospora subterranea, in Soil
In this study, a set of duplex reverse transcription (RT)-PCR-mediated high resolution DNA melting (HRM) analyses for simultaneous detection of potato mop-virus (PMTV) and its protist vector, Spongospora subterranea f.sp. subterranea (Sss), was developed.
The infestation of soil by PMTV was detected by using a tobacco-based baiting system. Total RNA extracted from the soil led to successful RT-PCR gel-electrophoresis detection of both PMTV and Sss. To facilitate more efficient detection, newly designed primer pairs for PMTV RNA species (i.e., RNA-Rep, -CP, and -TGB) were analyzed together with the existing Sss primers using real-time RT-PCR.
The resulting amplicons exhibited melting profiles that could be readily differentiated. Under duplex RT-PCR format, all PMTV and Sss primer combinations led to successful detection of respective PMTV RNA species and Sss in the samples by high resolution DNA melting (HRM) analyses. When the duplex HRM assay was applied to soil samples collected from six fields at four different sites in New Brunswick, Canada, positive detection of PMTV and/or Sss was found in 63-100% samples collected from fields in which PMTV-infected tubers had been observed.
In contrast, the samples from fields where neither PMTV- nor Sss-infected tubers had been observed resulted in negative detection by the assay. Bait tobacco bioassay for PMTV and Sss produced similar results. Between 63%-83% and 100% of the soil samples collected from PMTV-infested fields led to PMTV and Sss infections in the bait tobacco plants, respectively; whereas no PMTV or Sss infected plants were obtained from soil samples collected from PMTV/Sss-free fields.
PON1 mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) |
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| TA502612 | Origene Technologies GmbH | 100 µl | Ask for price |
PON1 mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) |
|||
| TA502612S | Origene Technologies GmbH | 30 µl | Ask for price |
Monoclonal PON1 Antibody, Clone: 4G8D3 |
|||
| AMR09437G | Leading Biology | 0.1ml | EUR 633.6 |
|
Description: A Monoclonal antibody against Human PON1. The antibodies are raised in Mouse and are from clone 4G8D3. This antibody is applicable in WB and IHC, FC, ICC, E |
|||
Rabbit Anti Human PON1 Monoclonal Clone ACAG-16 |
|||
| IRBAHUPON1ACAG16C100UL | Innovative research | each | EUR 496 |
|
Description: Rabbit Anti Human PON1 Monoclonal Clone ACAG-16 |
|||
Monoclonal PON1 Antibody, Clone: 4G8A12 |
|||
| AMM02955G | Leading Biology | 0.1ml | EUR 633.6 |
|
Description: A Monoclonal antibody against Human PON1. The antibodies are raised in Mouse and are from clone 4G8A12. This antibody is applicable in WB and IHC, FC, E |
|||
Monoclonal Antibody to Paraoxonase 1 (PON1) |
|||
| MAA243Ra21 | Cloud-Clone | 100ul | EUR 253 |
PON1 Mouse Monoclonal Antibody |
|||
| E10-30571 | EnoGene | 100 μl | EUR 275 |
|
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
|||
PON1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI1F7 |
|||
| TA600112 | Origene Technologies GmbH | 100 µg | Ask for price |
PON1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI2A6 |
|||
| TA600113 | Origene Technologies GmbH | 100 µg | Ask for price |
PON1 Capture mouse monoclonal antibody, ELISA and Luminex validated, clone OTI2D4 |
|||
| TA600114 | Origene Technologies GmbH | 100 µg | Ask for price |
Anti-PON1 Mouse Monoclonal Antibody [Clone ID: OTI1F7] |
|||
| M00516-4 | BosterBio | 100ul | EUR 523 |
|
Description: Boster Bio PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7). Catalog# M00516-4. Tested in ELISA, FC, IHC, WB. This antibody reacts with Human. |
|||
Anti-PON1 Mouse Monoclonal Antibody [Clone ID: OTI2D4] |
|||
| M00516-5 | BosterBio | 100ul | EUR 523 |
|
Description: Boster Bio PON1 mouse monoclonal antibody, clone OTI2D4 (formerly 2D4). Catalog# M00516-5. Tested in ELISA, FC, IF, IHC, WB. This antibody reacts with Human. |
|||
Mouse Monoclonal Antibody to PON1 |
|||
| E10-30571A | EnoGene | 100ul | EUR 225 |
|
Description: Available in various conjugation types. |
|||
Mouse Monoclonal Antibody to PON1 |
|||
| E10-30572 | EnoGene | 100ul | EUR 225 |
|
Description: Available in various conjugation types. |
|||
Mouse Monoclonal Antibody to PON1 |
|||
| sAP-0865 | Angio Proteomie | 50ug | EUR 270 |
Mouse Monoclonal Antibody to PON1 |
|||
| sAP-0866 | Angio Proteomie | 50ug | EUR 270 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527855-01mL | MyBiosource | 0.1mL | EUR 305 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527855-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527855-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527855-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527855-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527856-01mL | MyBiosource | 0.1mL | EUR 305 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527856-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527856-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527856-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
Mouse Monoclonal Antibody to PON1 |
|||
| MBS8527856-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
Mouse Monoclonal PON1 Antibody (4G8D3) |
|||
| TA336952 | Origene Technologies GmbH | 100 µl | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI2D4 (formerly 2D4) |
|||
| CF502528 | Origene Technologies GmbH | 100 µg | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI2A6 (formerly 2A6) |
|||
| CF502610 | Origene Technologies GmbH | 100 µg | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7) |
|||
| CF502611 | Origene Technologies GmbH | 100 µg | Ask for price |
Carrier-free (BSA/glycerol-free) PON1 mouse monoclonal antibody, clone OTI2A9 (formerly 2A9) |
|||
| CF502612 | Origene Technologies GmbH | 100 µg | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1A5 |
|||
| TA807382 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1A5 |
|||
| TA807382S | Origene Technologies GmbH | 30 µl | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1B12 |
|||
| TA807383 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody,clone OTI1B12 |
|||
| TA807383S | Origene Technologies GmbH | 30 µl | Ask for price |
Mouse Anti-HCMV gH Monoclonal Antibody, clone MAb 5 |
|||
| CABT-NS1153 | Creative Diagnostics | 200 μg | EUR 830 |
|
Description: Mouse |
|||
PON1 biotinylated detection antibody, ELISA and Luminex validated mouse monoclonal antibody, clone OTI2A6 |
|||
| TA700112 | Origene Technologies GmbH | 50 µg | Ask for price |
PON1 biotinylated detection antibody, ELISA and Luminex validated mouse monoclonal antibody, clone OTI2D4 |
|||
| TA700114 | Origene Technologies GmbH | 50 µg | Ask for price |
Mouse Anti-Ara h1 IgE Monoclonal Antibody (mAb), Clone 2G11G7 |
|||
| 7153 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Allergy |
|||
Mouse Anti-Ara h1 IgM Monoclonal Antibody (mAb), Clone 3A1E11 |
|||
| 7154 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Allergy |
|||
Mouse Monoclonal Anti-Mouse CD160 mAb, PE, (clone CNX46-3), (mouse IgG2bk) |
|||
| MCD160-PE | Alpha Diagnostics | 50 tests | EUR 416.4 |
CD20 (MS4A1) mouse monoclonal antibody, clone mAb 75 |
|||
| DDX0110P-100 | Origene Technologies GmbH | 100 µg | Ask for price |
KIR2DL4 mouse monoclonal antibody, clone mAb#33, PE |
|||
| AM26033RP-N | Origene Technologies GmbH | 100 Tests | Ask for price |
Mouse Monoclonal Anti-Mouse CD160 mAb, FITC, (clone CNX46-3), (mouse IgG2bk) |
|||
| MCD160-F | Alpha Diagnostics | 50 Tests | EUR 489.6 |
KIR2DL4 mouse monoclonal antibody, clone mAb#33, APC |
|||
| AM26033AC-N | Origene Technologies GmbH | 100 Tests | Ask for price |
Mouse Monoclonal Anti-Mouse CD160 mAb, Biotin, (clone CNX46-3), (mouse IgG2bk) |
|||
| MCD160-B | Alpha Diagnostics | 100 tests | EUR 562.8 |
PON3 mouse monoclonal antibody, clone OTI4H9 (formerly 4H9) |
|||
| TA807380 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI4H9 (formerly 4H9) |
|||
| TA807380S | Origene Technologies GmbH | 30 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5C3 (formerly 5C3) |
|||
| TA807381 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5C3 (formerly 5C3) |
|||
| TA807381S | Origene Technologies GmbH | 30 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5B5 (formerly 5B5) |
|||
| TA807428 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI5B5 (formerly 5B5) |
|||
| TA807428S | Origene Technologies GmbH | 30 µl | Ask for price |
Mouse Monoclonal Anti-Mouse CD160 mAb, Purified, (clone CNX46-3), (mouse IgG2bk) |
|||
| MCD160-M | Alpha Diagnostics | 100 ug | EUR 578.4 |
PON3 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12) |
|||
| TA807353 | Origene Technologies GmbH | 100 µl | Ask for price |
PON3 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12) |
|||
| TA807353S | Origene Technologies GmbH | 30 µl | Ask for price |
Mouse Anti Mouse BDNF Monoclonal Clone |
|||
| IMSAMLBDNFC120UL | Innovative research | each | EUR 341 |
|
Description: Mouse Anti Mouse BDNF Monoclonal Clone |
|||
Mouse Anti Mouse BDNF Monoclonal Clone |
|||
| MBS8421710-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti-Mouse Myeloperoxidase (MPO) IgM Monoclonal Antibody (mAb), Clone 8B3A6 |
|||
| 7160 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Inflammation |
|||
Mouse Anti-Mouse Myeloperoxidase (MPO) IgG3 Monoclonal Antibody (mAb), Clone 3B6A10 |
|||
| 7159 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Inflammation |
|||
KIR2DL4 mouse monoclonal antibody, clone mAb#33, Aff - Purified |
|||
| AM26033PU-N | Origene Technologies GmbH | 100 µg | Ask for price |
Ferritin mouse monoclonal antibody, clone mAb 44, Aff - Purified |
|||
| AM26062PU-N | Origene Technologies GmbH | 200 µg | Ask for price |
Mouse Anti Mouse TH Monoclonal Clone 5B7D10 |
|||
| IMSAMLTH5B7D10C120UL | Innovative research | each | EUR 282 |
|
Description: Mouse Anti Mouse TH Monoclonal Clone 5B7D10 |
|||
Mouse Anti Mouse TH Monoclonal Clone 5B7D10 |
|||
| MBS8421747-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti Mouse GFAP Monoclonal Clone 3H1 |
|||
| IMSAMLGFAP3H1C120UL | Innovative research | each | EUR 260 |
|
Description: Mouse Anti Mouse GFAP Monoclonal Clone 3H1 |
|||
Mouse Anti Mouse GFAP Monoclonal Clone 3H1 |
|||
| MBS8421725-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Rabbit Anti-Human PON1 Monoclonal Antibody |
|||
| CABT-36017RH | Creative Diagnostics | 100ug | EUR 1008 |
Mouse Anti Mouse tPA Monoclonal Clone H27B6 |
|||
| IMSAMSTPAH27B6C1MG | Innovative research | each | EUR 595 |
|
Description: Mouse Anti Mouse tPA Monoclonal Clone H27B6 |
|||
Monoclonal Functional BAFF-R (mouse) Antibody, mAb , Clone: 9B9 |
|||
| APR16043G | Leading Biology | 0.1mg | EUR 633.6 |
|
Description: A Monoclonal antibody against Human Functional BAFF-R (mouse), mAb . The antibodies are raised in Purified From Concentrated Hybridoma Tissue Culture Supernatant. and are from clone 9B9. This antibody is applicable in FC |
|||
Mouse monoclonal Anti-MOZ Clone 127A |
|||
| TA353278L | Origene Technologies GmbH | 500 µg | Ask for price |
ELISA andLuminex validated biotinylated detection antibody PON1 ELISA and Luminex validated mouse monoclonal antibody, clone OTI1F7 |
|||
| TA700113 | Origene Technologies GmbH | 50 µg | Ask for price |
Mouse Anti Mouse AIF1 Monoclonal Clone 5G4E7 |
|||
| IMSAMLAIF15G4E7C120UL | Innovative research | each | EUR 282 |
|
Description: Mouse Anti Mouse AIF1 Monoclonal Clone 5G4E7 |
|||
Mouse Anti Mouse AIF1 Monoclonal Clone 5G4E7 |
|||
| MBS8421709-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse monoclonal Anti-BCL10 Clone 151 |
|||
| TA352997L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CDX1 Clone 123a |
|||
| TA353093L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse Anti-D. pteronyssinus Der p2 IgM Monoclonal Antibody (mAb), Clone 2D2B12 |
|||
| 7157 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Allergy |
|||
Mouse Anti-D. pteronyssinus Der p1 IgG3 Monoclonal Antibody (mAb), Clone 3H4E1 |
|||
| 7158 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Allergy |
|||
Mouse Anti Mouse GFAP Monoclonal Clone 2B12F1 |
|||
| IMSAMLGFAP2B12F1C120UL | Innovative research | each | EUR 282 |
|
Description: Mouse Anti Mouse GFAP Monoclonal Clone 2B12F1 |
|||
Mouse Anti Mouse PPARG Monoclonal Clone 6D7B9 |
|||
| IMSAMLPPARG6D7B9C120UL | Innovative research | each | EUR 248 |
|
Description: Mouse Anti Mouse PPARG Monoclonal Clone 6D7B9 |
|||
Mouse Anti Mouse GFAP Monoclonal Clone 2B12F1 |
|||
| MBS8421724-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti Mouse PPARG Monoclonal Clone 6D7B9 |
|||
| MBS8421743-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse Anti-D. pteronyssinus Der p2 IgG2a Monoclonal Antibody (mAb), Clone 3H8D12 |
|||
| 7155 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Allergy |
|||
Mouse Anti-D. pteronyssinus Der p2 IgG2b Monoclonal Antibody (mAb), Clone 4C10H3 |
|||
| 7156 | Chondrex | 1 mg/ml x 0.1 ml | EUR 246 |
|
Description: Allergy |
|||
Mouse monoclonal Anti-Mos Clone S3.1 |
|||
| TA353341L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse Anti Human TUBB3 Monoclonal Clone |
|||
| IMSAMLTUBB3C120UL | Innovative research | each | EUR 341 |
|
Description: Mouse Anti Human TUBB3 Monoclonal Clone |
|||
Mouse Anti Human TUBB3 Monoclonal Clone |
|||
| MBS8421752-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Mouse monoclonal Anti-EMA Clone E29 |
|||
| TA352816L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CR1 Clone To5 |
|||
| TA353107L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-p63 Clone BU5 |
|||
| TA353532L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-XPA Clone 5A2 |
|||
| TA353547L | Origene Technologies GmbH | 500 µg | Ask for price |
Lipoprotein lipase (LPL) mouse monoclonal antibody, clone Mab-7, Purified |
|||
| BM5512 | Origene Technologies GmbH | 50 µg | Ask for price |
Mouse monoclonal Anti-FCGR1 Clone 10.1 |
|||
| TA352787L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-p13 Clone AA10.2 |
|||
| TA352924L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-ANO5 Clone 5F7 |
|||
| TA352973L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD68 Clone KP1 |
|||
| TA353054L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Cdk1 Clone 3E1.1 |
|||
| TA353088L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Cdk2 Clone AN4.3 |
|||
| TA353089L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD29 Clone 8E3 |
|||
| TA353270L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP1 Clone 3B6 |
|||
| TA353335L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP2 Clone 4D3 |
|||
| TA353336L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP3 Clone 1B4 |
|||
| TA353337L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MMP9 Clone 2C3 |
|||
| TA353338L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MUC1 Clone SM3 |
|||
| TA353346L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Plx Clone AZ34 |
|||
| TA353386L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Plx Clone AZ44 |
|||
| TA353387L | Origene Technologies GmbH | 500 µg | Ask for price |
PON1 Rabbit Monoclonal Antibody |
|||
| E10G21865 | EnoGene | 100 μl | EUR 275 |
|
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
|||
Mouse monoclonal Anti-APC11 Clone AX2.1 |
|||
| TA352969L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-APC4 Clone CIV1.1 |
|||
| TA352971L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD19 Clone BU12 |
|||
| TA353028L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD1c Clone M241 |
|||
| TA353030L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD22 Clone To15 |
|||
| TA353036L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD44 Clone P2A1 |
|||
| TA353042L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD44 Clone BU52 |
|||
| TA353043L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD70 Clone BU69 |
|||
| TA353057L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD72 Clone BU40 |
|||
| TA353059L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD86 Clone BU63 |
|||
| TA353067L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Leu2 Clone X107 |
|||
| TA353072L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Leu2 Clone BU88 |
|||
| TA353073L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Cdk2 Clone AN21.2 |
|||
| TA353090L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-BORIS Clone 4A7 |
|||
| TA353114L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CYP2C6 Clone K1 |
|||
| TA353125L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CYP3A1 Clone P6 |
|||
| TA353132L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-NSE Clone NSEP1 |
|||
| TA353161L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-NSE Clone NSEP2 |
|||
| TA353162L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-FGF3 Clone MSD1 |
|||
| TA353194L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-LewisX Clone 28 |
|||
| TA353199L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-INFa Clone ST29 |
|||
| TA353240L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PCNA Clone PC10 |
|||
| TA353373L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Cdc20 Clone BA8 |
|||
| TA353388L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PSMA5 Clone AH1.1 |
|||
| TA353401L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PTPRC Clone C11 |
|||
| TA353403L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-LAT1 Clone BU53 |
|||
| TA353464L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-TIMP1 Clone 2A5 |
|||
| TA353510L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-TIMP2 Clone 3A4 |
|||
| TA353511L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-WIPI2 Clone 2A2 |
|||
| TA353546L | Origene Technologies GmbH | 500 µg | Ask for price |
*Mouse Anti Mouse Prekallikrein Monoclonal Clone 5G7 |
|||
| IMSAMSPK5G7C100UG | Innovative research | each | EUR 315 |
|
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 5G7 |
|||
*Mouse Anti Mouse Prekallikrein Monoclonal Clone 5G7 |
|||
| IMSAMSPK5G7C1MG | Innovative research | each | EUR 2516 |
|
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 5G7 |
|||
*Mouse Anti Mouse Prekallikrein Monoclonal Clone 7G2 |
|||
| IMSAMSPK7G2C100UG | Innovative research | each | EUR 315 |
|
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 7G2 |
|||
*Mouse Anti Mouse PAI-1 Monoclonal Clone H14H7 |
|||
| IMSAMSPAI1H14H7C10MG | Innovative research | each | EUR 5964 |
|
Description: *Mouse Anti Mouse PAI-1 Monoclonal Clone H14H7 |
|||
*Mouse Anti Mouse PAI-1 Monoclonal Clone H14H7 |
|||
| IMSAMSPAI1H14H7C1MG | Innovative research | each | EUR 889 |
|
Description: *Mouse Anti Mouse PAI-1 Monoclonal Clone H14H7 |
|||
Mouse Anti Mouse PAI-1 Monoclonal Clone H34G6 |
|||
| IMSAMSPAI1H34G6C10MG | Innovative research | each | EUR 5964 |
|
Description: Mouse Anti Mouse PAI-1 Monoclonal Clone H34G6 |
|||
Mouse Anti Mouse PAI-1 Monoclonal Clone H34G6 |
|||
| IMSAMSPAI1H34G6C1MG | Innovative research | each | EUR 889 |
|
Description: Mouse Anti Mouse PAI-1 Monoclonal Clone H34G6 |
|||
Mouse monoclonal Anti-Leu1 Clone Y2/178 |
|||
| TA353051L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MHCII Clone BU20 |
|||
| TA352833L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Mglu3 Clone 4B92.1 |
|||
| TA352845L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-BCRABL Clone 7c6 |
|||
| TA352923L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-ASAP1 Clone 7B12 |
|||
| TA352983L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD22 Clone 4KB71 |
|||
| TA353035L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD44v3 Clone 3D2 |
|||
| TA353046L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD79a Clone HM57 |
|||
| TA353063L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD17a Clone HM47 |
|||
| TA353065L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PCTAIRE Clone G6.1 |
|||
| TA353087L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CLEC2 Clone AYP1 |
|||
| TA353099 | Origene Technologies GmbH | 100 µg | Ask for price |
Mouse monoclonal Anti-CLEC2 Clone AYP1 |
|||
| TA353099L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CLEC2 Clone AYP2 |
|||
| TA353100L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-Casein Clone F20.14 |
|||
| TA353112L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CYP1A2 Clone D15 |
|||
| TA353117L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-EGFR Clone EGFR1 |
|||
| TA353153L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-HRX Clone HRX107 |
|||
| TA353158L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-ENTPD1 Clone AC2 |
|||
| TA353163L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-EpCAM Clone AUA1 |
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| TA353166L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-ErbB3 Clone RTJ2 |
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| TA353168L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-ErbB4 Clone HFR1 |
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| TA353170L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-hFANCM Clone CV5.1 |
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| TA353183L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-FCGR2 Clone KB61 |
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| TA353190L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-ICAM3 Clone By44 |
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| TA353231L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD49b Clone 16B4 |
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| TA353247L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD49b Clone 31H4 |
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| TA353248L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD29 Clone 12G10 |
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| TA353269L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MDM2 Clone SMP14 |
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| TA353329L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CD20 Clone PDR78 |
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| TA353342L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-MUC1 Clone HMFG1 |
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| TA353348L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-RIP140 Clone 6D7 |
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| TA353369 | Origene Technologies GmbH | 100 µg | Ask for price |
Mouse monoclonal Anti-RIP140 Clone 6D7 |
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| TA353369L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PITPNB Clone 4a7 |
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| TA353380L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PITPNB Clone 1C1 |
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| TA353381L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PTPRC Clone 2B11 |
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| TA353406L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-PTPRC Clone BU64 |
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| TA353410L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-RACO1 Clone 5H10 |
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| TA353434L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-CDw75 Clone ZB55 |
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| TA353475L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-TAL1 Clone BTL73 |
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| TA353479L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-TAL1 Clone 2TL75 |
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| TA353480L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-TIGAR Clone 9C10 |
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| TA353508L | Origene Technologies GmbH | 500 µg | Ask for price |
Mouse monoclonal Anti-VEGF Clone VG76e |
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| TA353539L | Origene Technologies GmbH | 500 µg | Ask for price |
*Mouse Anti Mouse Prekallikrein Monoclonal Clone 11H4 |
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| IMSAMSPK11H4C100UG | Innovative research | each | EUR 315 |
|
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 11H4 |
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*Mouse Anti Mouse Prekallikrein Monoclonal Clone 11H4 |
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| IMSAMSPK11H4C1MG | Innovative research | each | EUR 2516 |
|
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 11H4 |
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*Mouse Anti Mouse Prekallikrein Monoclonal Clone 13G5 |
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| IMSAMSPK13G5C100UG | Innovative research | each | EUR 315 |
|
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 13G5 |
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*Mouse Anti Mouse Prekallikrein Monoclonal Clone 13G5 |
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| IMSAMSPK13G5C1MG | Innovative research | each | EUR 2516 |
|
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 13G5 |
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*Mouse Anti Mouse Prekallikrein Monoclonal Clone 14E3 |
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| IMSAMSPK14E3CBL100UG | Innovative research | each | EUR 379 |
|
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 14E3 |
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*Mouse Anti Mouse Prekallikrein Monoclonal Clone 14E3 |
|||
| IMSAMSPK14E3CBL1MG | Innovative research | each | EUR 2893 |
|
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 14E3 |
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*Mouse Anti Mouse Prekallikrein Monoclonal Clone 3A10 |
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| IMSAMSPK3A10C100UG | Innovative research | each | EUR 315 |
|
Description: *Mouse Anti Mouse Prekallikrein Monoclonal Clone 3A10 |
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